Relational correspondence in tone sandhi

Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Linguistics and Philosophy, 2007.Includes bibliographical references (p. 283-292).This dissertation proposes that the constraint component of OT grammars should be expanded to include a family of faithfulness constraints that evaluate input-output/output-output mappings for the preservation of gross Fo contours (rising, falling, level) across two or more segments. Following Steriade (2006), I refer to constraints in this family as Relational Correspondence constraints. The central tenet of Relational Correspondence is that phonological processes are shaped by pressure to maintain perceptual similarity between correspondent relations between successive elements, or syntagmatic contrast preservation in the auditory domain Fo, as opposed to paradigmatic contrast preservation according to which the well-formedness of an entity is evaluated with reference to the set of entities it contrasts with. Two types of Relational Correspondence are distinguished in this work: Contour and Slope Correspondence. Contour Correspondence, formulated as RELCORR constraints, assesses correspondence of the phonological height (Fo scaling) relation between successive tones. Four height relations are proposed for the tonal contour: "greater than" (x>y), "less than" (x<y), "equal to" (x=y), and "non-equal to" (x=/y). Preservation of the four scaling relations is contextualized with respect to different degrees of cohesiveness: nucleus-internal, word-internal and across words. Slope Correspondence, formulated as MATCH-SLOPE constraints, requires preservation of the steepness of the Fo contour across successive tones. Relational correspondence provides a unifying account for a number of seemingly unrelated tone sandhi phenomena in genetically diverse languages, while explaining empirical facts that cannot be adequately expressed within the standard Correspondence Theory of faithfulness plus markedness constraints.by Feng-fan Hsieh.Ph.D

A Study of the Phonetics and Phonology of Neutral Tones in Urumqi Chinese

[[abstract]]In this paper, we investigate neutral tones in Urumqi Chinese from the instrumental and theoretical perspectives. Our major finding contradicts a popular view in that neutral tones are primarily cued by shorter phonetic length. In this language, tonal neutralization is thus also attributable to difficulties in maintaining contrasts in a durationally diminished syllable. An OT analysis is subsequently provided to account for the phenomena found in the Urumqi Chinese data. In particular, we argue that there is a need for the notion of Kenstowicz’s (1996) UNIFORM EXPONENCE in analyzing phonetic realization of underlying tonal targets.[[fileno]]204_JA07_2008_v4_p57[[department]]語言學研究

On the Distribution of Neutral Tone in Southern Min: LCC and Beyond

The aim of this paper is to address an often-overlooked topic in Southern Min tonology: neutral tone. We show that the tone sandhi domain in Southern Min is not always isomorphic with an XP in syntax or a phonological phrase. In fact, this domain may be smaller than what has been predicted, as evidenced in the phrase-final functional morphemes as well as in the rhythmic effect. We propose that the tone sandhi domain in Southern Min is defined by a constituent Tone Sandhi Domain (TSD, τ) between the p-phrase and the p-word. A TSD is required to bear a final prominence, and only a p-word, mapped from a contentive or focused element in syntax, can be a “prominence-bearing unit.

Variegated VC Rime Restrictions in Sinitic Languages

In this study, we consider a non-Markedness-based account for VC rime phonotactics in Sinitic languages, with special reference to Taiwanese Southern Min and Hakka. Rime gaps in Chinese languages have been customarily analyzed as co-occurrence markedness constraints. But analyses along this line not only overgenerate by predicting unattested gaps, but also fail to motivate those phonotactic constraints in a principled fashion. By adopting Hsieh's (2010) duration-based account, we present further phonetic evidence to show that phonotactics of Chinese VC combinations may be attributed to: (i) low perceptibility of coda consonants due to absence of release, and (ii) decreased vowel distinctiveness as a result of vowel reduction. One of the new findings in this study is that the perceptual difficulties are further exacerbated by the relatively shorter duration of Taiwanese checked syllables, if compared with those of Hakka and Cantonese. Also, salient F2 transitions (vowel gliding) may occur to enhance the place of articulation of a stop coda in Taiwanese. Therefore, rime gaps are normally found in contexts whereby (i) VC coarticulation is weak and (ii) vowel distinctiveness cannot be maintained. In sum, the results of our acoustic studies suggest that the duration-based approach offers a more straightforward account for why Taiwanese has more rime gaps than Hakka and Cantonese do

Re-expression of ARHI (DIRAS3) induces autophagy in breast cancer cells and enhances the inhibitory effect of paclitaxel

<p>Abstract</p> <p>Background</p> <p><it>ARHI </it>is a Ras-related imprinted gene that inhibits cancer cell growth and motility. ARHI is downregulated in the majority of breast cancers, and loss of its expression is associated with its progression from ductal carcinoma <it>in situ </it>(DCIS) to invasive disease. In ovarian cancer, re-expression of ARHI induces autophagy and leads to autophagic death in cell culture; however, ARHI re-expression enables ovarian cancer cells to remain dormant when they are grown in mice as xenografts. The purpose of this study is to examine whether ARHI induces autophagy in breast cancer cells and to evaluate the effects of ARHI gene re-expression in combination with paclitaxel.</p> <p>Methods</p> <p>Re-expression of ARHI was achieved by transfection, by treatment with trichostatin A (TSA) or by a combination of TSA and 5-aza-2'-deoxycytidine (DAC) in breast cancer cell cultures and by liposomal delivery of ARHI in breast tumor xenografts.</p> <p>Results</p> <p>ARHI re-expression induces autophagy in breast cancer cells, and ARHI is essential for the induction of autophagy. When ARHI was re-expressed in breast cancer cells treated with paclitaxel, the growth inhibitory effect of paclitaxel was enhanced in both the cell culture and the xenografts. Although paclitaxel alone did not induce autophagy in breast cancer cells, it enhanced ARHI-induced autophagy. Conversely, ARHI re-expression promoted paclitaxel-induced apoptosis and G2/M cell cycle arrest.</p> <p>Conclusions</p> <p>ARHI re-expression induces autophagic cell death in breast cancer cells and enhances the inhibitory effects of paclitaxel by promoting autophagy, apoptosis, and G2/M cell cycle arrest.</p

Promoter polymorphisms of DNMT3B and the risk of colorectal cancer in Chinese: a case-control study

<p>Abstract</p> <p>Background</p> <p>DNA-methyltransferase-3B (DNMT3B), which plays a role in DNA methylation, is usually aberrant expression involved in carcinogenesis. Polymorphisms of the DNMT3B gene may influence DNMT3B activity on DNA methylation in several cancers, thereby modulating the susceptibility to cancer.</p> <p>Methods</p> <p>DNMT3B -579G>T genotypes and -149C>T were determined by PCR-RFLP and sequencing in 137 colorectal cancer patients and 308 controls matched for age and sex, who did not receive radiotherapy or chemotherapy for newly diagnosed and histopathologically confirmed colorectal cancer. The association between two SNPs of the <it>DNMT3B </it>promoter and the risk of the development of colorectal cancer was analyzed in a population of Chinese.</p> <p>Results</p> <p>The allele frequency of -149C >T among patients and controls was 0.73% versus 0.65%, respectively. The allele frequency of -597G>T for patients and controls was 6.57% versus 11.53%, respectively. Individuals with at least one -149C>T allele were no at a significantly increase risk of colorectal cancer compared with those having a -149TT genotype. However, Individuals with at least one 579G>T allele were decreased risk of colorectal cancer compared with those having a -579TT genotype.</p> <p>Conclusion</p> <p>The relative distribution of -149C>T <it>DNMT3B </it>SNPs among a Chinese population can not be used as a stratification marker to predict an individual's susceptibility to colorectal cancer. However, the DNMT3B -579G>T polymorphism may contribute to the genetic susceptibility to colorectal cancer.</p

Uncovering Natural Supersymmetry via the interplay between the LHC and direct Dark Matter detection

We have explored Natural Supersymmetry (NSUSY) scenarios with low values of the μ parameter which are characterised by higgsino-like Dark Matter (DM) and compressed spectra for the lightest MSSM particles, χ10, χ20 and χ1±. This scenario could be probed via monojet signatures, but as the signal-to-background ratio (S/B) is low we demonstrate that the 8 TeV LHC cannot obtain limits on the DM mass beyond those of LEP2. On the other hand, we have found, for the 13 TeV run of the LHC, that by optimising kinematical cuts we can bring the S/B ratio up to the 5(3)% level which would allow the exclusion of the DM mass up to 200(250) GeV respectively, significantly extending LEP2 limits. Moreover, we have found that LUX/XENON1T and LHC do play very complementary roles in exploring the parameter space of NSUSY, as the LHC has the capability to access regions where DM is quasi-degenerate with other higgsinos, which are challenging for direct detection experiments

Sustained proliferation in cancer: mechanisms and novel therapeutic targets

Proliferation is an important part of cancer development and progression. This is manifest by altered expression and/or activity of cell cycle related proteins. Constitutive activation of many signal transduction pathways also stimulates cell growth. Early steps in tumor development are associated with a fibrogenic response and the development of a hypoxic environment which favors the survival and proliferation of cancer stem cells. Part of the survival strategy of cancer stem cells may manifested by alterations in cell metabolism. Once tumors appear, growth and metastasis may be supported by overproduction of appropriate hormones (in hormonally dependent cancers), by promoting angiogenesis, by undergoing epithelial to mesenchymal transition, by triggering autophagy, and by taking cues from surrounding stromal cells. A number of natural compounds (e.g., curcumin, resveratrol, indole-3-carbinol, brassinin, sulforaphane, epigallocatechin-3-gallate, genistein, ellagitannins, lycopene and quercetin) have been found to inhibit one or more pathways that contribute to proliferation (e.g., hypoxia inducible factor 1, nuclear factor kappa B, phosphoinositide 3 kinase/Akt, insulin-like growth factor receptor 1, Wnt, cell cycle associated proteins, as well as androgen and estrogen receptor signaling). These data, in combination with bioinformatics analyses, will be very important for identifying signaling pathways and molecular targets that may provide early diagnostic markers and/or critical targets for the development of new drugs or drug combinations that block tumor formation and progression

Bone Marrow Support of the Heart in Pressure Overload Is Lost with Aging

Exogenous stem cell delivery is under investigation to prevent and treat cardiac dysfunction. It is less studied as to the extent endogenous bone marrow derived stem cells contribute to cardiac homeostais in response to stress and the affects of aging on this stress response.To determine the role of bone marrow (BM) derived stem cells on cardiac homeostasis in response to pressure overload (PO) and how this response is altered by aging.Young (8 weeks) and old (>40 weeks) C57/b6 mice underwent homo- and heterochronic BM transplantation prior to transverse aortic constriction (TAC). We found that older BM is associated with decreased cardiac function following TAC. This decreased function is associated with decrease in BM cell engraftment, increased myocyte apoptosis, decreased myocyte hypertrophy, increased myocardial fibrosis and decreased cardiac function. Additionally, there is a decrease in activation of resident cells within the heart in response to PO in old mice. Interestingly, these effects are not due to alterations in vascular density or inflammation in response to PO or differences in ex vivo stem cell migration between young and old mice.BM derived stem cells are activated in response to cardiac PO, and the recruitment of BM derived cells are involved in cardiac myocyte hypertrophy and maintenance of function in response to PO which is lost with aging